Journal article
Jonathan R. Weitz, Carol Jacques-Silva, Fahd Qadir, O. Umland, E. Pereira, Farhan Qureshi, Alejandro Tamayo, J. Domínguez-Bendala, R. Rodriguez-Diaz, Joana Almaça, A. Caicedo
Diabetes, 2020 Jun
Diabetes, 2020 Jun
Semantic Scholar
DOI
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APA
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Weitz, J. R., Jacques-Silva, C., Qadir, F., Umland, O., Pereira, E., Qureshi, F., … Caicedo, A. (2020). Secretory Functions of Macrophages in the Human Pancreatic Islet Are Regulated by Endogenous Purinergic Signaling. Diabetes.
Chicago/Turabian
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Weitz, Jonathan R., Carol Jacques-Silva, Fahd Qadir, O. Umland, E. Pereira, Farhan Qureshi, Alejandro Tamayo, et al. “Secretory Functions of Macrophages in the Human Pancreatic Islet Are Regulated by Endogenous Purinergic Signaling.” Diabetes (June 2020).
MLA
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Weitz, Jonathan R., et al. “Secretory Functions of Macrophages in the Human Pancreatic Islet Are Regulated by Endogenous Purinergic Signaling.” Diabetes, June 2020.
BibTeX Click to copy
@article{jonathan2020a,
title = {Secretory Functions of Macrophages in the Human Pancreatic Islet Are Regulated by Endogenous Purinergic Signaling},
year = {2020},
month = jun,
journal = {Diabetes},
author = {Weitz, Jonathan R. and Jacques-Silva, Carol and Qadir, Fahd and Umland, O. and Pereira, E. and Qureshi, Farhan and Tamayo, Alejandro and Domínguez-Bendala, J. and Rodriguez-Diaz, R. and Almaça, Joana and Caicedo, A.},
month_numeric = {6}
}
Abstract
Endocrine cells of the pancreatic islet interact with their microenvironment to maintain tissue homeostasis. Communication with local macrophages is particularly important in this context, but the homeostatic functions of human islet macrophages are not known. In this study, we show that the human islet contains macrophages in perivascular regions that are the main local source of the anti-inflammatory cytokine interleukin-10 (IL-10) and the metalloproteinase MMP9. Macrophage production and secretion of these homeostatic factors are controlled by endogenous purinergic signals. In obese and diabetic states, macrophage expression of purinergic receptors MMP9 and IL-10 is reduced. We propose that in those states, exacerbated β-cell activity due to increased insulin demand and increased cell death produce high levels of ATP that downregulate purinergic receptor expression. Loss of ATP sensing in macrophages may reduce their secretory capacity.
