APA
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Qadir, F., Bhondeley, M., Beatty, W., Gaupp, D., Doyle-Meyers, L., Fischer, T., … Mauvais-Jarvis, F. (2021). SARS-CoV-2 infection of the pancreas promotes thrombofibrosis and is associated with new-onset diabetes. JCI Insight.
Chicago/Turabian
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Qadir, Fahd, Manika Bhondeley, W. Beatty, D. Gaupp, L. Doyle-Meyers, T. Fischer, I. Bandyopadhyay, et al. “SARS-CoV-2 Infection of the Pancreas Promotes Thrombofibrosis and Is Associated with New-Onset Diabetes.” JCI insight (2021).
MLA
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Qadir, Fahd, et al. “SARS-CoV-2 Infection of the Pancreas Promotes Thrombofibrosis and Is Associated with New-Onset Diabetes.” JCI Insight, 2021.
BibTeX Click to copy
@article{fahd2021a,
title = {SARS-CoV-2 infection of the pancreas promotes thrombofibrosis and is associated with new-onset diabetes},
year = {2021},
journal = {JCI insight},
author = {Qadir, Fahd and Bhondeley, Manika and Beatty, W. and Gaupp, D. and Doyle-Meyers, L. and Fischer, T. and Bandyopadhyay, I. and Blair, R. and Bohm, R. and Rappaport, J. and Lazartigues, E. and Heide, R. V. Vander and Kolls, J. and Qin, X. and Mauvais-Jarvis, F.}
}
Evidence suggests an association between severe acute respiratory syndrome–cornavirus-2 (SARS-CoV-2) infection and the occurrence of new-onset diabetes. We examined pancreatic expression of angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2), the cell entry factors for SARS-CoV-2, using publicly available single-cell RNA sequencing data sets, and pancreatic tissue from control male and female nonhuman primates (NHPs) and humans. We also examined SARS-CoV-2 immunolocalization in pancreatic cells of SARS-CoV-2–infected NHPs and patients who had died from coronavirus disease 2019 (COVID-19). We report expression of ACE2 in pancreatic islet, ductal, and endothelial cells in NHPs and humans. In pancreata from SARS-CoV-2–infected NHPs and COVID-19 patients, SARS-CoV-2 infected ductal, endothelial, and islet cells. These pancreata also exhibited generalized fibrosis associated with multiple vascular thrombi. Two out of 8 NHPs developed new-onset diabetes following SARS-CoV-2 infection. Two out of 5 COVID-19 patients exhibited new-onset diabetes at admission. These results suggest that SARS-CoV-2 infection of the pancreas may promote acute and especially chronic pancreatic dysfunction that could potentially lead to new-onset diabetes.
